Article
Segregation of a single outboard left-end origin is essential for the viability of parvovirus minute virus of mice.
Journal of virology - 1 Nov 2006
Burnett Erik, Cotmore Susan F, Tattersall Peter
Abstract excerpt
During DNA replication, the hairpin telomeres of Minute Virus of Mice (MVM) are extended and copied to create imperfectly palindromic duplex junction sequences that bridge adjacent genomes in concatameric replicative-form DNA. These are resolved by the viral initiator protein, NS1, but mechanisms employed at the two telomeres differ. Left-end:left-end junctions are resolved asymmetrically at a single site,...
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