Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Construction of a Severe Acute Respiratory Syndrome Coronavirus Infectious cDNA Clone and a Replicon To Study Coronavirus RNA Synthesis

15 Oct 2006

Abstract excerpt

The engineering of a full-length infectious cDNA clone and a functional replicon of the severe acute respiratory syndrome coronavirus (SARS-CoV) Urbani strain as bacterial artificial chromosomes (BACs) is described in this study. In this system, the viral RNA was expressed in the cell nucleus under the control of the cytomegalovirus promoter and further amplified in the cytoplasm by the viral replicase. Both the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16928748
DOI: 10.1128/jvi.00385-06

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Construction of a Severe Acute Respiratory Syndrome Coronavirus Infectious cDNA Clone and a Replicon To Study Coronavirus RNA SynthesisPMID 16928748Read ↗

Engineering the largest RNA virus genome as an infectious bacterial artificial chromosomeSemantic proximity Read ↗

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirusSemantic proximity Read ↗

Construction and characterization of two SARS‐CoV‐2 minigenome replicon systemsSemantic proximity Read ↗

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screeningSemantic proximity Read ↗

Infectious RNA transcribed in vitro from a cDNA copy of the human coronavirus genome cloned in vaccinia virusSemantic proximity Read ↗

A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses.Semantic proximity Read ↗

Rapid Generation of Reverse Genetics Systems for Coronavirus Research and High‐Throughput Antiviral Screening Using Gibson DNA AssemblySemantic proximity Read ↗

A rapid and versatile reverse genetics approach for generating recombinant positive-strand RNA viruses that use IRES-mediated translationSemantic proximity Read ↗

Establishment of a Reverse Genetics System for SARS-CoV-2 Using Circular Polymerase Extension ReactionSemantic proximity Read ↗

Reverse Genetics System for the Avian Coronavirus Infectious Bronchitis VirusSemantic proximity Read ↗

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine CandidateSemantic proximity Read ↗

Construction of a non-infectious SARS coronavirus replicon for application in drug screening and analysis of viral protein functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.