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Article

Cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein.

The Journal of biological chemistry - 20 Oct 2006

Mueller Mareike, Stamme Cordula, Draing Christian, Hartung Thomas, Seydel Ulrich, Schromm Andra B

Abstract excerpt

Lipoteichoic acid (LTA) represents immunostimulatory molecules expressed by Gram-positive bacteria. They activate the innate immune system via Toll-like receptors. We have investigated the role of serum proteins in activation of human macrophages by LTA from Staphylococcus aureus and found it to be strongly attenuated by serum. In contrast, the same cells showed a sensitive response to LTA and a significantly...

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Source

Identifiers

PMID: 16928689
DOI: 10.1074/jbc.M605966200

Genes

LBP
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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