Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2013

Soares Elyara M, Mason Katie L, Rogers Lisa M, Serezani Carlos H, Faccioli Lucia H, Aronoff David M

Abstract excerpt

Puerperal sepsis is a leading cause of maternal mortality worldwide. Streptococcus pyogenes [group A Streptococcus; (GAS)] is a major etiologic agent of severe postpartum sepsis, yet little is known regarding the pathogenesis of these infections. Tissue macrophages provide innate defense against GAS, and their actions are highly regulated. The intracellular second messenger cAMP can negatively regulate macrophage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonate 5-Lipoxygenase
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Sepsis

Share to Streptococcal Infections

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 23325886
DOI: 10.4049/jimmunol.1202932
PMCID: PMC3563855

Genes

LTB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes.PMID 23325886Read ↗

Induction and termination of inflammatory signaling in group B streptococcal sepsisSemantic proximity Read ↗

Inducible Cyclooxygenase Released Prostaglandin E2 Modulates the Severity of Infection Caused by Streptococcus pyogenesSemantic proximity Read ↗

An impaired inflammatory cytokine response to gram-negative LPS in human neonates is associated with the defective TLR-mediated signaling pathway.Semantic proximity Read ↗

Infection with <i>Listeria monocytogenes</i> alters the placental transcriptome and eicosanomeSemantic proximity Read ↗

Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections.Semantic proximity Read ↗

Mechanisms of group B Streptococcus-mediated preterm birth: lessons learnt from animal modelsSemantic proximity Read ↗

The phenotype and function of preterm infant monocytes: implications for susceptibility to infectionSemantic proximity Read ↗

Lipopolysaccharide-induced premature cervical ripening and inflammation in pregnant mice can be alleviated by nicotineSemantic proximity Read ↗

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.Semantic proximity Read ↗

A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of the TLR2/MyD88 Pathway in MicrogliaSemantic proximity Read ↗

Sphingosine 1-Phosphate Activates S1PR3 to Induce a Proinflammatory Phenotype in Human Myometrial Cells.Semantic proximity Read ↗

Prostacyclin synthase deficiency exacerbates inflammatory reactions in lipopolysaccharide-induced sepsis in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.