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Article

Reduced dNTP interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer.

The Journal of biological chemistry - 27 Oct 2006

Operario Darwin J, Balakrishnan Mini, Bambara Robert A, Kim Baek

Abstract excerpt

We have recently demonstrated that HIV-1 RT mutants characterized by low dNTP binding affinity display significantly reduced dNTP incorporation kinetics in comparison to wild-type RT. This defect is particularly emphasized at low dNTP concentrations where WT RT remains capable of efficient synthesis. Kinetic interference in DNA synthesis can induce RT pausing and slow down the synthesis rate. RT stalling and slow...

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Share to Deoxyribonucleotides
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16926150
DOI: 10.1074/jbc.M604665200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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