Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Melanoma Differentiation Associated Gene-7/Interleukin-24 Promotes Tumor Cell-Specific Apoptosis through Both Secretory and Nonsecretory Pathways

1 May 2004

Abstract excerpt

Melanoma differentiation associated gene-7/interleukin-24 (Mda-7/IL-24), a novel member of the IL-10 family of cytokines, uniquely displays cancer-specific apoptosis-inducing activity. Positive results in ongoing phase I/II clinical trials have strengthened the possibility of its utilization as a cancer gene therapeutic. Previous studies document that signaling events leading to Ad.mda-7-induced transformed cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Toxin Mechanisms and Immunotoxins
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15126330
DOI: 10.1158/0008-5472.can-04-0200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanoma Differentiation Associated Gene-7/Interleukin-24 Promotes Tumor Cell-Specific Apoptosis through Both Secretory and Nonsecretory PathwaysPMID 15126330Read ↗

Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (<i>mda</i>-7/IL-24)Semantic proximity Read ↗

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24Semantic proximity Read ↗

MDA-7/IL-24 as a cancer therapeutic: from bench to bedsideSemantic proximity Read ↗

Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing ProteinSemantic proximity Read ↗

Melanoma differentiation associated gene-7 (mda-7)/IL-24: a ‘magic bullet’ for cancer therapy?Semantic proximity Read ↗

The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-24Semantic proximity Read ↗

mda-7/IL-24 Mediates Cancer Cell–Specific Death via Regulation of miR-221 and the Beclin-1 AxisSemantic proximity Read ↗

<i>Mda‐7</i>/<i>IL‐24</i> induces apoptosis of diverse cancer cell lines through JAK/STAT‐independent pathwaysSemantic proximity Read ↗

<i>mda-</i> 7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPKSemantic proximity Read ↗

MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancerSemantic proximity Read ↗

Is <i>mda-7/IL-24</i> a “Magic Bullet” for Cancer?Semantic proximity Read ↗

Expression, purification, and characterization of RGD-mda-7, a His-tagged mda-7/IL-24 mutant protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.