Article
A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study.
The Prostate - 1 Oct 2006
Zheng S Lilly, Liu Wennuan, Wiklund Fredrik, Dimitrov Latchezar, Bälter Katarina, Sun Jielin, Adami Hans-Olov, Johansson Jan-Erik, Sun Jishan, Chang Baoli, Loza Matthew, Turner Aubrey R, Bleecker Eugene R, Meyers Deborah A, Carpten John D, Duggan David, Isaacs William B, Xu Jianfeng, Grönberg Henrik
Abstract excerpt
BACKGROUND: Recently identified associations of prostate cancer risk with several genes involved in innate immunity support a role of inflammation in the etiology of prostate cancer. Considering inflammation is regulated by a complex system of gene products, we hypothesize sequence variants in many other genes of this pathway are associated with prostate cancer. METHODS: We evaluated 9,275 SNPs in 1,086 genes of...
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