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Article

The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene.

The Journal of biological chemistry - 20 Oct 2006

Kirschner Karin M, Wagner Nicole, Wagner Kay-Dietrich, Wellmann Sven, Scholz Holger

Abstract excerpt

Cell-matrix interaction through specific adhesion molecules is a critical step during organ development. In addition, down-regulation of cell adhesion receptors may promote tumor invasion and metastasis. We show here that the Wilms tumor suppressor Wt1, which is necessary for normal development of the epicardium, coronary vessels, genitourinary system, and other tissues, activates transcription of the...

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Source

Identifiers

PMID: 16920711
DOI: 10.1074/jbc.M602668200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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