Article
Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish.
Molecular medicine reports - 1 Sept 2016
Powell Rebecca, Bubenshchikova Ekaterina, Fukuyo Yayoi, Hsu Chaonan, Lakiza Olga, Nomura Hiroki, Renfrew Erin, Garrity Deborah, Obara Tomoko
Abstract excerpt
Wilm's tumor 1 interacting protein (Wtip) was identified as an interacting partner of Wilm's tumor protein (WT1) in a yeast two-hybrid screen. WT1 is expressed in the proepicardial organ (PE) of the heart, and mouse and zebrafish wt1 knockout models appear to lack the PE. Wtip's role in the heart remains unexplored. In the present study, we demonstrate that wtip expression is identical in wt1a‑, tcf21‑, and...
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