Article
Results of a genome-wide genetic screen for panic disorder.
American journal of medical genetics - 28 Mar 1998
Knowles J A, Fyer A J, Vieland V J, Weissman M M, Hodge S E, Heiman G A, Haghighi F, de Jesus G M, Rassnick H, Preud'homme-Rivelli X, Austin T, Cunjak J, Mick S, Fine L D, Woodley K A, Das K, Maier W, Adams P B, Freimer N B, Klein D F, Gilliam T C
Abstract excerpt
Panic disorder is characterized by spontaneous and recurrent panic attacks, often accompanied by agoraphobia. The results of family, twin, and segregation studies suggest a genetic role in the etiology of the illness. We have genotyped up to 23 families that have a high density of panic disorder with 540 microsatellite DNA markers in a first-pass genomic screen. The thirteen best families (ELOD > 6.0 under the...
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