Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform.

Human mutation - 1 Oct 2006

Bergin Ann-Marie, Balder Barbro, Kishore Shivendra, Swärd Kajsa, Hahn-Zoric Mirjana, Löwhagen Olle, Hanson Lars A, Padyukov Leonid

Abstract excerpt

We previously found the soluble interleukin 4 receptor (sIL4R) to be differently expressed in allergic asthma patients compared to healthy individuals. Here we present data demonstrating the involvement of the sequence variations, c.912-1003A > G, c.912-833T > C, c. 912-630A > G, and c.912-577A > G, in the expressional regulation of IL4R splice variants. By using an IL4R minigene construct, genomic DNA and mRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Interleukin-4

Share to RNA-Binding Proteins

Share to RNA Splicing

Share to RNA Splicing Factors

Share to Serine-Arginine Splicing Factors

Share to Solubility

Source

Identifiers

PMID: 16917945
DOI: 10.1002/humu.20364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common variations in the IL4R gene affect splicing and influence natural expression of the soluble isoform.PMID 16917945Read ↗

A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.Semantic proximity Read ↗

A novel polymorphism in the 5' promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels.Semantic proximity Read ↗

Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis.Semantic proximity Read ↗

Haplotypes of the interleukin-4 receptor alpha chain gene associate with susceptibility to and severity of atopic asthma.Semantic proximity Read ↗

Interleukin and interleukin receptor diversity: role of alternative splicing.Semantic proximity Read ↗

A second-generation association study of the 5q31 cytokine gene cluster and the interleukin-4 receptor in asthma.Semantic proximity Read ↗

Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants.Semantic proximity Read ↗

Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences.Semantic proximity Read ↗

Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthmaSemantic proximity Read ↗

IL4RA gene expression in relation to I50V, Q551R and C-3223T polymorphisms.Semantic proximity Read ↗

The human IL-23 receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA species.Semantic proximity Read ↗

Soluble interleukin‐6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.