"Activated" keratinocyte phenotype is unifying feature in conditions which predispose to squamous cell carcinoma of the skin.

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Article

"Activated" keratinocyte phenotype is unifying feature in conditions which predispose to squamous cell carcinoma of the skin.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 1990

Smoller B R, Krueger J, McNutt N S, Hsu A

Abstract excerpt

While some cutaneous squamous cell carcinomas (SCC) arise from predisposing conditions such as burn scars, draining sinuses, and chronic, nonhealing wounds, the vast majority of these tumors arise from actinically damaged epidermis. It has been shown previously that keratinocytes within healing wounds show an "activated" immunophenotype when stained with antibodies to psi-3, involucrin, filaggrin, and...

Topics

Aged
Aged, 80 and over
Antibodies, Monoclonal
Carcinoma, Squamous Cell
Epidermis
Female
Filaggrin Proteins
Humans
Intermediate Filament Proteins
Keratinocytes
Keratins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Keratosis

Male

Middle Aged

Phenotype

Precancerous Conditions

Protein Precursors

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 1691494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1691494-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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