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Clinicopathologic and Genetic Analysis of Inverted Follicular Keratosis With Emphasis on Its Similarity to Seborrheic Keratosis.

Journal of cutaneous pathology - 1 Jun 2026

Kobayashi Anna, Goto Keisuke, Takai Toshihiro, Minami Tomoya, Matsumoto Koji, Fujimoto Masayo, Kukita Yoji, Kajimoto Kazuyoshi, Ito Tomoo

Abstract excerpt

The classification of inverted follicular keratosis (IFK) remains controversial, with debate on whether it represents a variant of seborrheic keratosis, a follicular poroma (folliculosebaceous poroma), or a distinct tumor type. To clarify, we conducted genetic analyses to detect FGFR3 and PIK3CA mutations, as well as PAK1/2/3 rearrangements, in IFK cases. IFK was diagnosed based on exo-endophytic or endophytic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41850715
DOI: 10.1111/cup.70093

Genes

PIK3CA
FGFR3
PAK1
PAK3

Variants

Provenance

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