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Article

Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case series.

Journal of Alzheimer's disease : JAD - 1 Aug 2006

Tsuang Debby W, Riekse Robert G, Purganan Kristina M, David Andrew C, Montine Thomas J, Schellenberg Gerard D, Steinbart Ellen J, Petrie Eric C, Bird Thomas D, Leverenz James B

Abstract excerpt

BACKGROUND: Lewy body pathology (LBP) is a common finding in Alzheimer's disease (AD), but the pathophysiology for this coexistent pathology remains unclear. METHODS: We ascertained late-onset dementia (mean age > 60 years old) families with at least 3 autopsies. We then conducted systematic alpha-synuclein (SNCA) immunostaining to determine the frequency and distribution of LBP in families with late-onset AD....

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Source

Identifiers

PMID: 16914833
DOI: 10.3233/jad-2006-9302

Genes

LBP
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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