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Article

Differential regulation of germline apoptosis in response to meiotic checkpoint activation.

Genetics - 1 Nov 2014

Ye Alice L, Ragle J Matthew, Conradt Barbara, Bhalla Needhi

Abstract excerpt

In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.

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Source

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Identifiers

PMID: 25217053
DOI: 10.1534/genetics.114.170241
PMCID: PMC4224185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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