Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos.

doi:10.1128/mcb.10.4.1452-1460.1990

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Article

Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos.

Molecular and cellular biology - 1 Apr 1990

Wu H, Bateman J F, Schnieke A, Sharpe A, Barker D, Mascara T, Eyre D, Bruns R, Krimpenfort P, Berns A

Abstract excerpt

To investigate whether the human pro alpha 1(I) collagen chain could form an in vivo functional interspecies heterotrimer with the mouse pro alpha 2(I) collagen chain, we introduced the human COL1A1 gene into Mov13 mice which have a functional deletion of the endogenous COL1A1 gene. Transgenic mouse strains (HucI and HucII) carrying the human COL1A1 gene were first generated by microinjecting the COL1A1 gene into...

Topics

Animals
Blotting, Northern
Bone and Bones
Collagen
DNA
Embryo, Mammalian
Genes
Genes, Lethal
Humans
Macromolecular Substances
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Mice, Transgenic

Mutation

Phenotype

Procollagen

RNA

Skin

Source

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Identifiers

PMID: 1690840
DOI: 10.1128/mcb.10.4.1452-1460.1990
PMCID: PMC362247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1690840-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos.PMID 1690840Read ↗

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