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Article

The tumour suppressor hSNF5/INI1 controls the differentiation potential of malignant rhabdoid cells.

European journal of cancer (Oxford, England : 1990) - 1 Sept 2006

Albanese Patricia, Belin Marie-France, Delattre Olivier

Abstract excerpt

Malignant rhabdoid tumours (MRT) are highly aggressive cancers of early childhood that arise in different organs or tissues. The unifying criterion for these tumours is the presence of inactivating mutations of the hSNF5/INI1 tumour suppressor gene which encodes a core subunit of the chromatin remodelling SWI/SNF complex. Using a variety of markers we analysed the phenotypic traits of MON and DEV cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16908131
DOI: 10.1016/j.ejca.2006.03.028

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The tumour suppressor hSNF5/INI1 controls the differentiation potential of malignant rhabdoid cells.PMID 16908131Read ↗

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Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

hSNF5/INI1 inactivation is mainly associated with homozygous deletions and mitotic recombinations in rhabdoid tumors.Semantic proximity Read ↗

<i>Aurora A</i> Is a Repressed Effector Target of the Chromatin Remodeling Protein INI1/hSNF5 Required for Rhabdoid Tumor Cell SurvivalSemantic proximity Read ↗

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.Semantic proximity Read ↗

SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor DevelopmentSemantic proximity Read ↗

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice.Semantic proximity Read ↗

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Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors.Semantic proximity Read ↗

SNF5 Reexpression in Malignant Rhabdoid Tumors Regulates Transcription of Target Genes by Recruitment of SWI/SNF Complexes and RNAPII to the Transcription Start Site of Their PromotersSemantic proximity Read ↗

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