Article
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.
Nature - 9 Jul 1998
Versteege I, Sévenet N, Lange J, Rousseau-Merck M F, Ambros P, Handgretinger R, Aurias A, Delattre O
Abstract excerpt
Malignant rhabdoid tumours (MRTs) are extremely aggressive cancers of early childhood. They can occur in various locations, mainly the kidney, brain and soft tissues. Cytogenetic and molecular analyses have shown that the deletion of region 11.2 of the long arm of chromosome 22 (22q11.2) is a rec...
Topics
- Child
- Chromosomal Proteins, Non-Histone
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 22
- DNA-Binding Proteins
- Frameshift Mutation
- Humans
- Infant
- Infant, Newborn
- Mutation
- Rhabdoid Tumor
- SMARCB1 Protein
- Transcription Factors
- Tumor Cells, Cultured