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Article

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.

Nature - 9 Jul 1998

Versteege I, Sévenet N, Lange J, Rousseau-Merck M F, Ambros P, Handgretinger R, Aurias A, Delattre O

Abstract excerpt

Malignant rhabdoid tumours (MRTs) are extremely aggressive cancers of early childhood. They can occur in various locations, mainly the kidney, brain and soft tissues. Cytogenetic and molecular analyses have shown that the deletion of region 11.2 of the long arm of chromosome 22 (22q11.2) is a recurrent genetic characteristic of MRTs, indicating that this locus may encode a tumour suppressor gene. Here we map the...

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Identifiers

PMID: 9671307
DOI: 10.1038/28212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.PMID 9671307Read ↗

Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations.Semantic proximity Read ↗

Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors.Semantic proximity Read ↗

Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers.Semantic proximity Read ↗

Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

hSNF5/INI1‐deficient tumours and rhabdoid tumours are convergent but not fully overlapping entitiesSemantic proximity Read ↗

Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors.Semantic proximity Read ↗

Molecular genetics of atypical teratoid/rhabdoid tumor.Semantic proximity Read ↗

INI1 mutations in meningiomas at a potential hotspot in exon 9.Semantic proximity Read ↗

Rhabdoid Tumor of the Kidney is a Component of the Rhabdoid Predisposition SyndromeSemantic proximity Read ↗

INI1-Deficient TumorsSemantic proximity Read ↗

Chromosome 22q Deletions in Atypical Teratoid/Rhabdoid Tumors in AdultsSemantic proximity Read ↗

Mutations of the hSNF5/INI1 gene in renal rhabdoid tumors with second primary brain tumors.Semantic proximity Read ↗

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