Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

hSNF5/INI1 inactivation is mainly associated with homozygous deletions and mitotic recombinations in rhabdoid tumors.

Cancer research - 1 Jul 1999

Rousseau-Merck M F, Versteege I, Legrand I, Couturier J, Mairal A, Delattre O, Aurias A

Abstract excerpt

The chromatin-remodeling hSNF5/INI1 gene has recently been shown to act as a tumor suppressor gene in rhabdoid tumors (RTs). In an attempt to further characterize the main chromosomal mechanisms involved in hSNF5/INI1 inactivation in RTs, we report here the molecular cytogenetic data obtained in 12 cell lines harboring hSNF5/INI1 mutations and/or deletions in relation to the molecular genetic analysis using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Proteins, Non-Histone
Share to Chromosomes, Human, Pair 22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Consensus Sequence

Share to Genes, Tumor Suppressor

Share to Mitosis

Share to Rhabdoid Tumor

Share to SMARCB1 Protein

Share to Translocation, Genetic

Source

Identifiers

PMID: 10397258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

hSNF5/INI1 inactivation is mainly associated with homozygous deletions and mitotic recombinations in rhabdoid tumors.PMID 10397258Read ↗

Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations.Semantic proximity Read ↗

hSNF5/INI1‐deficient tumours and rhabdoid tumours are convergent but not fully overlapping entitiesSemantic proximity Read ↗

Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors.Semantic proximity Read ↗

Chromosome mechanisms and INI1 inactivation in human and mouse rhabdoid tumors.Semantic proximity Read ↗

The tumour suppressor hSNF5/INI1 controls the differentiation potential of malignant rhabdoid cells.Semantic proximity Read ↗

A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle.Semantic proximity Read ↗

<i>Aurora A</i> Is a Repressed Effector Target of the Chromatin Remodeling Protein INI1/hSNF5 Required for Rhabdoid Tumor Cell SurvivalSemantic proximity Read ↗

Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers.Semantic proximity Read ↗

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.Semantic proximity Read ↗

[Infant rhabdoid tumors: a diagnostic emergency].Semantic proximity Read ↗

Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.