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Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches.

Annals of human genetics - 1 Sept 2006

Carothers A D, Rudan I, Kolcic I, Polasek O, Hayward C, Wright A F, Campbell H, Teague P, Hastie N D, Weber J L

Abstract excerpt

We have used genealogies and genomic polymorphisms to estimate individual inbreeding coefficients (F) in 50 subjects with an expected range (based on recent genealogies) of F from 0.0 to 0.0625. The estimates were based on two approaches, using genotypes respectively from 410 microsatellite markers (410-STR panel) and from 10,000 SNPs (10K-SNP panel). The latter was performed in a sub-sample of 15 individuals. We...

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PMID: 16907711
DOI: 10.1111/j.1469-1809.2006.00263.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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