Article
Genome survey for loci that influence successful aging: results at 10-cM resolution.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Mar 2007
Zubenko George S, Hughes Hugh B, Zubenko Wendy N, Maher Brion S
Abstract excerpt
OBJECTIVE: A systematic genome survey was initiated to identify loci that affect the likelihood of reaching age 90 with preserved cognition (successful aging). METHODS: The genome survey was conducted at 10-cM resolution for simple sequence tandem repeat polymorphisms (SSTRPs) that identify genes for Successful AGing (SAG loci) by virtue of linkage disequilibrium. Efficiency was enhanced by genotyping pools of...
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