Article
Family-based versus unrelated case-control designs for genetic associations.
PLoS genetics - 1 Aug 2006
Evangelou Evangelos, Trikalinos Thomas A, Salanti Georgia, Ioannidis John P A
Abstract excerpt
The most simple and commonly used approach for genetic associations is the case-control study design of unrelated people. This design is susceptible to population stratification. This problem is obviated in family-based studies, but it is usually difficult to accumulate large enough samples of well-characterized families. We addressed empirically whether the two designs give similar estimates of association in 93...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.