Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

L-SIGN (CD209L) isoforms differently mediate trans-infection of hepatoma cells by hepatitis C virus pseudoparticles.

The Journal of general virology - 1 Sept 2006

Falkowska Emilia, Durso Robert J, Gardner Jason P, Cormier Emmanuel G, Arrigale Robert A, Ogawa Raymond N, Donovan Gerald P, Maddon Paul J, Olson William C, Dragic Tatjana

Abstract excerpt

L-SIGN is a C-type lectin that is expressed on liver sinusoidal endothelial cells. Capture of Hepatitis C virus (HCV) by this receptor results in trans-infection of hepatoma cells. L-SIGN alleles have been identified that encode between three and nine tandem repeats of a 23 residue stretch in the juxtamembrane oligomerization domain. Here, it was shown that these repeat-region isoforms are expressed at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C

Share to Hepatocytes

Share to Lectins, C-Type

Share to Minisatellite Repeats

Share to Receptors, Virus

Share to Viral Envelope Proteins

Source

Identifiers

PMID: 16894195
DOI: 10.1099/vir.0.82034-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L-SIGN (CD209L) isoforms differently mediate trans-infection of hepatoma cells by hepatitis C virus pseudoparticles.PMID 16894195Read ↗

The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads.Semantic proximity Read ↗

Differential Use of the C‐Type Lectins L‐<scp>SIGN</scp> and <scp>DC‐SIGN</scp> for Phlebovirus EndocytosisSemantic proximity Read ↗

Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulationSemantic proximity Read ↗

Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus.Semantic proximity Read ↗

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users.Semantic proximity Read ↗

Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteinsSemantic proximity Read ↗

Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity.Semantic proximity Read ↗

Optimised cell systems for the investigation of hepatitis C virus E1E2 glycoproteinsSemantic proximity Read ↗

The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection.Semantic proximity Read ↗

Expression of the human or porcine C-type lectins DC-SIGN/L-SIGN confers susceptibility to porcine epidemic diarrhea virus entry and infection in otherwise refractory cell linesSemantic proximity Read ↗

West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.Semantic proximity Read ↗

R753Q single-nucleotide polymorphism impairs toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.