Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PKCtheta expression in gastrointestinal stromal tumor.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2006

Kim Kyoung-Mee, Kang Dong Wook, Moon Woo Sung, Park Jae Bok, Park Cheol Keun, Sohn Jin Hee, Jeong Jin Sook, Cho Mee-Yon, Jin So-Young, Choi Jong Sang, Kang Dae Young

Abstract excerpt

Gastrointestinal stromal tumor is characterized by a gain of function mutation of KIT gene and the expression of c-kit protein, but in 5% of cases, c-kit expression is negative although histological findings of gastrointestinal stromal tumor are most suspicious. The existence of c-kit-negative gastrointestinal stromal tumors points to the need of additional markers for making the diagnosis. In this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evaluation Studies as Topic

Share to Gastrointestinal Stromal Tumors

Share to Protein Kinase C

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to S100 Proteins

Source

Identifiers

PMID: 16892012
DOI: 10.1038/modpathol.3800673

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PKCtheta expression in gastrointestinal stromal tumor.PMID 16892012Read ↗

Diagnostic significance of DOG-1 and PKC-θ expression and c-Kit/PDGFRA mutations in gastrointestinal stromal tumoursSemantic proximity Read ↗

Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs).Semantic proximity Read ↗

DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors.Semantic proximity Read ↗

Diagnostic relevance of overexpressions of PKC-θ and DOG-1 and KIT/PDGFRA gene mutations in extragastrointestinal stromal tumors: a Korean six-centers study of 28 cases.Semantic proximity Read ↗

Gastrointestinal stromal tumors (GISTs): CD117, DOG-1 and PKCθ expression. Is there any advantage in using several markers?Semantic proximity Read ↗

KIT-negative gastrointestinal stromal tumor of the abdominal soft tissue: a clinicopathologic and genetic study of 10 cases.Semantic proximity Read ↗

Mutations of the c-Kit and PDGFRA gene in gastrointestinal stromal tumors among hakka population of Southern China.Semantic proximity Read ↗

PDGFRalpha- and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features.Semantic proximity Read ↗

An immunohistochemical and molecular study of gastrointestinal stromal tumours.Semantic proximity Read ↗

Pathological characteristics of gastrointestinal stromal tumours with PDGFRA mutations.Semantic proximity Read ↗

c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue).Semantic proximity Read ↗

PDGFRA immunostaining can help in the diagnosis of gastrointestinal stromal tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.