Article
Molecular profiling of chronic myeloid leukemia in eastern India.
American journal of hematology - 1 Nov 2006
Mondal Bama C, Bandyopadhyay Aditi, Majumdar Sunipa, Mukhopadhyay Ashis, Chandra Sarmila, Chaudhuri Utpal, Chakrabarti Prantar, Bhattacharyya Shibashish, Dasgupta Uma B
Abstract excerpt
Molecular breakpoint of the BCR-ABL fusion gene has been characterized for 122 chronic myeloid leukemia patients. Out of 122 cases, 33 b2a2, 69 b3a2, 2 e1a2, and 2 e19a2 cases have been detected. Six coexpressed both b2a2 and b3a2 transcripts. All the coexpressing samples had an A>G polymorphism at the putative splice branchpoint in intron 13. The T>C polymorphism in exon 13, reported to be linked to...
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