Article
Non-equilibrium theory of the allele frequency spectrum.
Theoretical population biology - 1 Feb 2007
Evans Steven N, Shvets Yelena, Slatkin Montgomery
Abstract excerpt
A forward diffusion equation describing the evolution of the allele frequency spectrum is presented. The influx of mutations is accounted for by imposing a suitable boundary condition. For a Wright-Fisher diffusion with or without selection and varying population size, the boundary condition is lim(x downward arrow0)xf(x,t)=thetarho(t), where f(.,t) is the frequency spectrum of derived alleles at independent loci...
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