Article
Regulated expression of human beta-defensin-2 leads to altered phenotype and growth patterns of cultured human embryonal kidney cells.
Experimental oncology - 1 Dec 2006
Zhuravel E, Lytvyn D, Soldatkina M, Zeleniy S, Shestakova T, Pogrebnoy P
Abstract excerpt
AIM: To create cell line with regulated expression of human beta-defensin-2 (hBD-2) and evaluate the influence of expressed peptide on its phenotypic and growth patterns. MATERIALS AND METHODS: Using cloning techniques, on the base of human embryonic kidney cells of HEK293T line, stable T-rex HEK-hBD2-m cell subline expressing mature biologically active hBD-2 molecule upon the presence of tetracycline in culture...
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