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Article

Determinants of Sensitivity and Resistance to Rapamycin-Chemotherapy Drug Combinations In vivo

1 Aug 2006

Abstract excerpt

The phosphatidylinositol-3-OH kinase [PI(3)K] pathway is frequently activated in human cancers and represents a rational target for therapeutic intervention. We have previously shown that enforced expression of Akt, which is a downstream effector of PI(3)K, could promote tumorigenesis and drug resistance in the Emu-myc mouse lymphoma model, and that these tumors were particularly sensitive to inhibition of...

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PMID: 16885364
DOI: 10.1158/0008-5472.can-06-0419

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