Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping of human herpesvirus 6 immediate-early 2 protein transactivation domains.

Virology - 10 Oct 2006

Tomoiu Andru, Gravel Annie, Flamand Louis

Abstract excerpt

The immediate-early 2 (IE2) protein of human herpesvirus 6 (HHV-6) is a potent transactivator of multiple cellular and viral promoters. Deletion mutants of HHV-6 variant A IE2 allowed us to map functional transactivation domains acting on complex and minimal promoter sequences. This mapping showed that both the N-terminal and C-terminal domains of IE2 are required for efficient transactivation, and that deletion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Genes, Reporter
Share to Herpesvirus 6, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immediate-Early Proteins

Share to Luciferases

Share to Microscopy, Fluorescence

Share to Sequence Deletion

Share to Transcriptional Activation

Source

Identifiers

PMID: 16884756
DOI: 10.1016/j.virol.2006.06.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping of human herpesvirus 6 immediate-early 2 protein transactivation domains.PMID 16884756Read ↗

Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins.Semantic proximity Read ↗

Inhibition of Transcription of the Beta Interferon Gene by the Human Herpesvirus 6 Immediate-Early 1 ProteinSemantic proximity Read ↗

Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains.Semantic proximity Read ↗

Small Internal Deletions in the Human Cytomegalovirus IE2 Gene Result in Nonviable Recombinant Viruses with Differential Defects in Viral Gene ExpressionSemantic proximity Read ↗

CD4 promoter transactivation by human herpesvirus 6.Semantic proximity Read ↗

The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulationSemantic proximity Read ↗

Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latencySemantic proximity Read ↗

An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoter.Semantic proximity Read ↗

Human Herpesvirus 6 Immediate-Early 1 Protein Is a Sumoylated Nuclear Phosphoprotein Colocalizing with Promyelocytic Leukemia Protein-associated Nuclear BodiesSemantic proximity Read ↗

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein.Semantic proximity Read ↗

Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start siteSemantic proximity Read ↗

A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.