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Article

Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts.

Genes, brain, and behavior - 1 Jul 2006

Bennett B, Carosone-Link P

Abstract excerpt

Quantitative trait locus (QTL) mapping is often done in a single segregating population, such as a backcross or an intercross. Both QTL location and effect size are then estimated from the same dataset. This approach results in an over-estimate of effect size for two reasons: (1) LOD scores, which are maximized over numerous point-wise tests, are correlated with estimated effect size and (2) small effect QTLs are...

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PMID: 16879634
DOI: 10.1111/j.1601-183X.2005.00174.x

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