Article
Genomewide scan and fine mapping of quantitative trait loci for intraocular pressure on 5q and 14q in West Africans.
Investigative ophthalmology & visual science - 1 Aug 2006
Rotimi Charles N, Chen Guanjie, Adeyemo Adebowale A, Jones Leslie S, Agyenim-Boateng Kofi, Eghan Benjamin A, Zhou Jie, Doumatey Ayo, Lashley Karrie, Huang Hanxia, Fasanmade Olufemi, Akinsola Folasade B, Ezepue Felix, Amoah Albert, Akafo Stephen, Chen Yuanxiu, Oli Johnnie, Johnson Thomas
Abstract excerpt
PURPOSE: High intraocular pressure (IOP) is a major risk factor for glaucoma, one of the leading causes of blindness worldwide. Because it has been demonstrated that African populations are at increased risk for glaucoma, the authors investigated the genetic basis of IOP in a sample of West Africans with type 2 diabetes (T2D) from Ghana and Nigeria. METHODS: Genomewide linkage analysis was conducted for loci...
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