Article
[The role of the constitutional features and rearrangement of the H-ras 1 oncogene in the development of human lung cancer].
Voprosy meditsinskoi khimii - 1 Jan 2000
Nikiforova I F, Maksimishina M G, Lemekhov V G, Kniazev P G
Abstract excerpt
Length polymorphism of restriction fragments of oncogene HRASI was studied in 52 patients with lung cancer as compared with corresponding normal tissues and leukocytes of these patients and of healthy volunteers. Enhanced frequency of one of main alleles of HRASI A4 was found to correlate with development of the disease aggressive symptoms. Alterations in the HRASI locus of tumoral DNA appear to correlate...
Topics
- Alleles
- DNA, Neoplasm
- Gene Expression
- Genes, ras
- Humans
- Lung Neoplasms
- Male
- Mutation
- Neoplasm Metastasis
- Polymorphism, Restriction Fragment Length