Article
Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours.
Histology and histopathology - 1 Nov 2006
Diedrich A, Bock H C, König F, Schulz T G, Ludwig H C, Herken R, Quondamatteo F
Abstract excerpt
Glutathione S-transferases (GSTs) play a central role in a number of metabolic processes. Glutathione S-transferase T1 (GSTT1) is a polymorphic cytosolic enzyme and a member of the theta class of GSTs. Typical substrates for GSTT1 are industrial compounds, such as dichloromethane and ethylene oxide. It has been shown that also chemotherapeutic drugs such as BCNU [i.e. 1,3-bis(2-chloroethyl)-1-nitrosourea] are...
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