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Article

O6-methylguanine-DNA methyltransferase gene(MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation

20 Aug 1999

Abstract excerpt

Repair of cytotoxic DNA damage by O(6)-methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CENUs), commonly used in the treatment of glioblastoma multiforme (GBM). The value of p53 as a prognostic factor in GBMs remains unclear, but a possible relationship between MGMT gene expression and p53 has been suggested. To further examine these GBM...

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Identifiers

PMID: 10404096
DOI: 10.1002/(sici)1097-0215(19990820)84:4<416::aid-ijc15>3.0.co;2-a

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