Article
Genetic markers of fibrinolytic responses of older persons to exercise training.
International journal of sports medicine - 1 Aug 2006
Kulaputana O, Ghiu I, Phares D A, Ferrell R E, Macko R F, Goldberg A P, Hagberg J M
Abstract excerpt
We assessed the interactive effect of genetic polymorphisms and exercise training on fibrinolysis in 50 - 75 yr old men (n = 17) and women (n = 28). Subjects had tissue plasminogen activator (t-PA) antigen levels and activity and plasminogen activator inhibitor-1 (PAI-1) activity measured before and after 6 mo of endurance-exercise training. Subject's DNA was typed for the PAI-1 4 G/5 G and t-PA I/D variants....
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