Article
GSTM1 and GSTT1 null genotypes as possible heritable factors of rosacea.
Photodermatology, photoimmunology & photomedicine - 1 Aug 2006
Yazici Ayca Cordan, Tamer Lulufer, Ikizoglu Guliz, Kaya Tamer Irfan, Api Hale, Yildirim Hatice, Adiguzel Aynur
Abstract excerpt
PURPOSE: Rosacea might be related to an increased activity of reactive oxygen species (ROS) and deficient function of the antioxidant system. Glutathione S-transferases (GSTs) play a primer role in cellular defense against electrophilic chemical species and radical oxygen species. We hypothesized that increased ROS activity or decreased antioxidant potential, possibly induced by GST gene polymorphism, might have...
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