Article
Classifying severity of cystic fibrosis lung disease using longitudinal pulmonary function data.
American journal of respiratory and critical care medicine - 1 Oct 2006
Schluchter Mark D, Konstan Michael W, Drumm Mitchell L, Yankaskas James R, Knowles Michael R
Abstract excerpt
RATIONALE: The study of genetic modifiers in cystic fibrosis (CF) lung disease requires rigorous phenotyping. One type of genetic association study design compares polymorphisms in patients at extremes of phenotype, requiring accurate classification of pulmonary disease at varying ages. OBJECTIVE: To evaluate approaches to quantify severity of pulmonary disease and their ability to discriminate between patients...
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