Article
Heritability of lung disease severity in cystic fibrosis.
American journal of respiratory and critical care medicine - 15 May 2007
Vanscoy Lori L, Blackman Scott M, Collaco Joseph M, Bowers Amanda, Lai Teresa, Naughton Kathleen, Algire Marilyn, McWilliams Rita, Beck Suzanne, Hoover-Fong Julie, Hamosh Ada, Cutler Dave, Cutting Garry R
Abstract excerpt
RATIONALE: Obstructive lung disease, the major cause of mortality in cystic fibrosis (CF), is poorly correlated with mutations in the disease-causing gene, indicating that other factors determine severity of lung disease. OBJECTIVES: To quantify the contribution of modifier genes to variation in CF lung disease severity. METHODS: Pulmonary function data from patients with CF living with their affected twin or...
Topics
- Adolescent
- Adult
- Child
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Female
- Forced Expiratory Volume
- Genetic Variation
- Humans
- Lung Diseases
- Male
- Severity of Illness Index
- Twins, Dizygotic