Article
The complexity of the mammalian transcriptome.
The Journal of physiology - 1 Sept 2006
Gustincich Stefano, Sandelin Albin, Plessy Charles, Katayama Shintaro, Simone Roberto, Lazarevic Dejan, Hayashizaki Yoshihide, Carninci Piero
Abstract excerpt
A comprehensive understanding of protein and regulatory networks is strictly dependent on the complete description of the transcriptome of cells. After the determination of the genome sequence of several mammalian species, gene identification is based on in silico predictions followed by evidence of transcription. Conservative estimates suggest that there are about 20,000 protein-encoding genes in the mammalian...
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