Article
Hereditary breast cancer.
Annual review of medicine - 1 Jan 1998
Ellisen L W, Haber D A
Abstract excerpt
Genetic predisposition is responsible for 5-10% of all breast cancer, and a much larger percent of early-onset disease. Within the past few years, a number of genes associated with a high risk of breast cancer have been identified, including BRCA1, BRCA2, p53, and the Cowden disease gene PTEN/MMAC1. These genes appear to function as tumor suppressors, and although their mutation frequency in the general...
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