Article
Association between achalasia and nitric oxide synthase gene polymorphisms.
The American journal of gastroenterology - 1 Sept 2006
Mearin Fermín, García-González María-Asunción, Strunk Michael, Zárate Natalia, Malagelada Juán-Ramón, Lanas Angel
Abstract excerpt
BACKGROUND: Our group previously reported the absence of nitric oxide synthase (NOS) in the gastroesophageal junction of patients with achalasia. NOS exists in three distinct isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible isoform (iNOS). Some studies have shown that NO production is regulated by NOS polymorphisms. AIM: To assess whether some functional polymorphisms in the nNOS, iNOS, or...
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