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Article

High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11).

Genes, chromosomes & cancer - 1 Oct 2006

Wieland Ilse, Muschke Petra, Volleth Marianne, Röpke Albrecht, Pelz Antje-Friederike, Stumm Markus, Wieacker Peter

Abstract excerpt

In a family with a high incidence of postmenopausal breast cancer and a case of glioblastoma, the constitutional translocation t(11;22)(q23;q11.2) was shown to segregate with the malignancies. The breakpoints in this family coincided with the common breakpoints in t(11;22) as shown by a translocation-specific PCR assay. Loss of heterozygosity analysis of breast tumor tissue revealed deletion of the normal...

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Identifiers

PMID: 16845657
DOI: 10.1002/gcc.20358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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