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Article

Regulation of cytokinesis by spindle-pole bodies.

Nature cell biology - 1 Aug 2006

Magidson Valentin, Chang Fred, Khodjakov Alexey

Abstract excerpt

In the fission yeast Schizosaccharomyces pombe, cytokinesis is thought to be controlled by the daughter spindle-pole body (SPB) through a regulatory pathway named the septation initiation network (SIN). Here, we demonstrate that laser ablation of both, but not a single SPB, results in failure of cytokinesis. Ablation of only the daughter SPB often leads to activation of the SIN on the mother SPB and successful...

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Identifiers

PMID: 16845379
DOI: 10.1038/ncb1449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of cytokinesis by spindle-pole bodies.PMID 16845379Read ↗

Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1.Semantic proximity Read ↗

Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).Semantic proximity Read ↗

Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.Semantic proximity Read ↗

Isolation and characterization of new fission yeast cytokinesis mutants.Semantic proximity Read ↗

The spindle pole bodies facilitate nuclear envelope division during closed mitosis in fission yeast.Semantic proximity Read ↗

Modeling the septation initiation network (SIN) in fission yeast cells.Semantic proximity Read ↗

Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast.Semantic proximity Read ↗

Timely septation requires SNAD-dependent spindle pole body localization of the septation initiation network components in the filamentous fungus Aspergillus nidulans.Semantic proximity Read ↗

Identification of functional domains within the septation initiation network kinase, Cdc7.Semantic proximity Read ↗

Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis.Semantic proximity Read ↗

An Extended, Boolean Model of the Septation Initiation Network in S.Pombe Provides Insights into Its Regulation.Semantic proximity Read ↗

Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint.Semantic proximity Read ↗

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