Article
Neopterin induces pro-atherothrombotic phenotype in human coronary endothelial cells.
Journal of thrombosis and haemostasis : JTH - 1 Oct 2006
Cirillo P, Pacileo M, DE Rosa S, Calabrò P, Gargiulo A, Angri V, Granato-Corigliano F, Fiorentino I, Prevete N, DE Palma R, Mauro C, Leonardi A, Chiariello M
Abstract excerpt
BACKGROUND: Inflammation plays a pivotal role in atherothrombosis. Recent data indicate that serum levels of neopterin, a marker of inflammation and immune modulator secreted by monocytes/macrophages, are elevated in patients with acute coronary syndromes and seem to be a prognostic marker for major cardiovascular events. The aim of the present study was to determine whether neopterin might affect the thrombotic...
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