Article
Dietary lipid lowering modifies plaque phenotype in rabbit atheroma after angioplasty: a potential role of tissue factor.
Circulation - 7 Oct 2003
Jeanpierre Emmanuelle, Le Tourneau Thierry, Six Isabelle, Zawadzki Christophe, Van Belle Eric, Ezekowitz Michael D, Bordet Régis, Susen Sophie, Jude Brigitte, Corseaux Delphine
Abstract excerpt
BACKGROUND: Tissue factor (TF), the main initiator of blood coagulation, is involved in cellular migration and angiogenesis processes. TF is expressed strongly in lipid-rich plaques and probably plays an important role in the thrombotic complications of plaque rupture. This study analyzes the effect of dietary lipid lowering on TF expression and cellular modifications in angioplasty-induced rabbit plaque rupture....
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