Article
Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants.
American journal of physiology. Heart and circulatory physiology - 1 Oct 2007
Carluccio Maria Annunziata, Ancora Maria Assunta, Massaro Marika, Carluccio Marisa, Scoditti Egeria, Distante Alessandro, Storelli Carlo, De Caterina Raffaele
Abstract excerpt
Hyperhomocysteinemia is a recognized risk factor for vascular disease, but pathogenetic mechanisms involved in its vascular actions are largely unknown. Because VCAM-1 expression is crucial in monocyte adhesion and early atherogenesis, we evaluated the NF-kappaB-related induction of VCAM-1 by homocysteine (Hcy) and the possible inhibitory effect of dietary polyphenolic antioxidants, such as trans-resveratrol...
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