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Article

Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.

Gut - 1 Feb 2007

Karrar A, Broomé U, Uzunel M, Qureshi A R, Sumitran-Holgersson S

Abstract excerpt

BACKGROUND: The liver may have a role in peripheral tolerance, by serving as a site for trapping, apoptosis and phagocytosis of activated T cells. It is not known which hepatic cells are involved in these processes. It was hypothesised that liver sinusoidal endothelial cells (LSEC) which are strategically placed for participation in the regulation of sinusoidal blood flow, and express markers involved in...

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Identifiers

PMID: 16840505
DOI: 10.1136/gut.2006.093906
PMCID: PMC1856767

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Source receipt: pubmed, retrieved 7 Sept 2026.

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