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Article

Nuclear Retention of Multiply Spliced HIV-1 RNA in Resting CD4+ T Cells

2 Jul 2006

Abstract excerpt

HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in patients on highly active antiretroviral therapy (HAART). We describe here a novel post-transcriptional block in HIV-1 gene expression in resting CD4+ T cells from patients on HAART. This block involves the aberrant localization of multiply spliced (MS) HIV-1 RNAs encoding the critical positive regulators Tat and Rev....

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PMID: 16839202
DOI: 10.1371/journal.ppat.0020068

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