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Article

Rapid genetic analysis of families with polycystic kidney disease 1 by means of a microsatellite marker.

Lancet (London, England) - 14 Dec 1991

Harris P C, Thomas S, Ratcliffe P J, Breuning M H, Coto E, Lopez-Larrea C

Abstract excerpt

Presymptomatic diagnosis of polycystic kidney disease 1 (PKD1) is possible by genetic linkage analysis with markers from both sides of the disease locus. The existing proximal markers are not informative in many families, so such analysis is difficult and time-consuming. We sought more useful length polymorphisms on the proximal side of the locus among simple sequence repeats (microsatellites). We identified two...

Topics

Alleles
Base Sequence
Chromosomes, Human, Pair 16
Cosmids
DNA
Genetic Testing
Humans
Lod Score
Molecular Sequence Data
Nucleotide Mapping
Polycystic Kidney, Autosomal Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Identifiers

PMID: 1683919
DOI: 10.1016/0140-6736(91)92300-q

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1683919-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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