Article
Restrictive fragment length polymorphisms of markers 3'HVR and 24-1 and their applications in gene diagnosis of adult polycystic disease in Chinese.
Chinese medical journal - 1 Jan 1994
Zhang S Z, Ding L, Yu Y L, Hu Y, Luo N F, Zhang S X, Li H
Abstract excerpt
Adult polycystic kidney disease was diagnosed with pedigree analysis using polymorphic DNA markers linked to the disease gene in 5 families. The markers were thoroughly characterized in the population. We noted two important markers, 3'HVR and 24-1, which flank the disease gene PKD1 in normal Chinese. Southern hybridization was used, and numerous 3'HVR/PvuII polymorphic allelic bands varied from 1.4 kb to 8.0 kb...
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